A running gag of the openings is Kel never knowing what the night's episode would be about and Kenan refusing to tell him, while the closings frequently feature Kenan coming up with a new scheme, often asking Kel to get various assorted items and meet him somewhere. Usually they do stuff that relates to the episode itself, for example, in the opening of 'The Tainting of the Screw', Kel is seen wearing fishing gear, and the episode is about Kenan choking on a screw that was in his tuna sandwich. Episodes open and close with Kenan and Kel breaking the fourth wall by interacting with a studio audience, standing in front of a red curtain that is placed in front of the main set while they are still in character. The show employs a number of running gags. These schemes are often foiled as a result of Kel's aloof, happy-go-lucky nature. Set in Chicago, Illinois, Kenan & Kel follows Kenan Rockmore and Kel Kimble, a pair of high school students who go on various misadventures, which usually occur as a result of Kenan devising a scheme to get rich quick, or avoid trouble with his elders. The last two seasons were taped at the now closed theater Nickelodeon on Sunset in Los Angeles, California. The first two seasons were taped at Nickelodeon Studios at Universal Studios Florida. After the conclusion of the series, it was followed by the television film Two Heads Are Better Than None (2000). It won the 'Favorite TV Show' award at the 1998 Kids' Choice Awards.

Kenan & Kel features appearances from a number of guest stars, including game show host/radio disc jockey Bob Eubanks, basketball player Ron Harper, and singer Britney Spears. The show also features Kenan's boss Chris Potter ( Dan Frischman). The show features Kenan's family, which consists of his father Roger ( Ken Foree), mother Sheryl ( Teal Marchande), and younger sister Kyra ( Vanessa Baden). Set in Chicago, Illinois, the series follows mischievous Kenan Rockmore ( Kenan Thompson) and his optimistic but dimwitted best friend Kel Kimble ( Kel Mitchell), who go on a number of misadventures. The show originally aired on the Nickelodeon network for four seasons, from July 15, 1996, to July 15, 2000.

Kenan & Kel is an American buddy comedy sitcom created by Kim Bass.

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